- Tabea Brick, MPH
- Dr. rer. biol. hum. Martin Depner
- Dr. med. Oliver Fuchs, MD PhD (Bern)
- Stefanie Heidmann
- Alexander Hose, MA MPH
- Dr.rer.med. Sabina Illi, MPH
- Nicola Korherr, Project Assistant
- Johanna Kurz, BSc
- Dr. rer. nat. Antje Legatzki
- Susanne Müller-Rompa, MPH
- Dr. med. Barbara Rösler (formerly Unkel), MD
- Elisabeth Schmaußer-Hechfellner, BSc
Tabea Brick, MPH
Tabea Brick joined the Asthma and Allergy Research Group in 2014. After finishing her Master Thesis (ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow’s milk, Brick et al.) she started to work there as research assistant. The main topic of her PhD thesis is the analysis of different milk ingredients accountable for the protective farm-milk effect on asthma.
- 2009 - 2013
- BA Social work at the University of Applied Sciences Munich
- 2013 - 2015
- Master of Public Health at the LMU Munich
Dr. rer. biol. hum. Martin Depner
Martin Depner holds a degree in psychology, and is specialised in mathematics and statistics. He also has experience in empirical social research including planning, implementation, analysis and quality management of studies.
2005 he joined the group at the Hauner’sches Children Hospital of Munich where his focus was first the analysis of genetic association studies in asthma and allergy research. He wrote his doctoral thesis about genetic determinants of asthma (methods and application). 2010, he finished a postgraduate education in medical biometry with a focus on interaction analysis in genetics. To get customized with analysis of next generation sequence data, he spent six months in the institute of human genetics of the University of Chicago under supervision of Prof. Dan Nicolae http://www.stat.uchicago.edu/~nicolae/ and participated in different workshops on genomics.
He is currently working on microbiome studies (analysing 16sRNA data), but also involved in different European farm studies with a special interest on phenotypes of asthma and allergies and new methodological considerations in these topics.
Depner, M., O. Fuchs, J. Genuneit, A. M. Karvonen, A. Hyvarinen, V. Kaulek, C. Roduit, J. Weber, B. Schaub, R. Lauener, M. Kabesch, P. I. Pfefferle, U. Frey, J. Pekkanen, J. C. Dalphin, J. Riedler, C. Braun-Fahrlander, E. von Mutius and M. J. Ege (2014). "Clinical and epidemiologic phenotypes of childhood asthma." Am J Respir Crit Care Med 189(2): 129-138.
Lluis, A., M. Depner*, B. Gaugler, P. Saas, V. I. Casaca, D. Raedler, S. Michel, J. Tost, J. Liu, J. Genuneit, P. Pfefferle, M. Roponen, J. Weber, C. Braun-Fahrlander, J. Riedler, R. Lauener, D. A. Vuitton, J. C. Dalphin, J. Pekkanen, E. von Mutius and B. Schaub (2014). "Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood." J Allergy Clin Immunol 133(2): 551-559.
Depner, M., M. J. Ege, J. Genuneit, J. Pekkanen, M. Roponen, M. R. Hirvonen, J. C. Dalphin, V. Kaulek, S. Krauss-Etschmann, J. Riedler, C. Braun-Fahrlander, C. Roduit, R. Lauener, P. I. Pfefferle, J. Weber and E. von Mutius (2013). "Atopic sensitization in the first year of life." J Allergy Clin Immunol 131(3): 781-788.
Illi, S., M. Depner*, J. Genuneit, E. Horak, G. Loss, C. Strunz-Lehner, G. Buchele, A. Boznanski, H. Danielewicz, P. Cullinan, D. Heederik, C. Braun-Fahrlander and E. von Mutius (2012). "Protection from childhood asthma and allergy in Alpine farm environments-the GABRIEL Advanced Studies." J Allergy Clin Immunol 129(6): 1470-1477 e1476.
Moffatt, M. F., M. Kabesch, L. Liang, A. L. Dixon, D. Strachan, S. Heath, M. Depner, A. von Berg, A. Bufe, E. Rietschel, A. Heinzmann, B. Simma, T. Frischer, S. A. Willis-Owen, K. C. Wong, T. Illig, C. Vogelberg, S. K. Weiland, E. von Mutius, G. R. Abecasis, M. Farrall, I. G. Gut, G. M. Lathrop and W. O. Cookson (2007). "Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma." Nature 448(7152): 470-473.
* shared first authorship
Dr. med. Oliver Fuchs, MD PhD (Bern)
After medical training in Heidelberg, Munich, Lund, and Boston and his graduation from Medical School in Munich in 2004, Oliver Fuchs obtained his doctoral degree (MD) in 2005 and was trained in General Paediatrics and Neonatal Intensive Care at the Dr. von Hauner Children’s Hospital of Ludwig Maximilian University in Munich. From 2008 to 2012, he was a research fellow and PhD candidate under supervision of Urs Frey in the Division of Paediatric Pulmonology at the University Children’s Hospital Bern, Switzerland, and since 2011 also at the University Children’s Hospital Basel, Switzerland. He obtained his PhD at the Graduate School for Biomedical and Cellular Science in Bern, Switzerland in 2012. During his stay in Switzerland, his main research focused on genetic and environmental determinants (both protective and risk factors) on the development of lung disease during childhood, asthma epidemiology and infant and child respiratory physiology. After returning to the Dr von Hauner Children’s Hospital in Munich in 2012 he joined the Asthma and Allergy Research Group and is now working as a clinician researcher in the frame of the German Center for Lung Research . His current focus is on establishing a clinical cohort of children with wheeze and asthma in order to improve diagnostics, prevention and therapy of childhood asthma, in order to better define phenotypes of childhood asthma and to improve our understanding of the different molecular and cellular mechanisms involved.
1. Fuchs O, Genuneit J, Latzin P, Büchele G, Horak E, Loss G, Sozanska B, Weber J, Boznanski A, Heederik D, Braun-Fahrländer C, Frey U, von Mutius E, GABRIELA Study Group. Farming environments and childhood atopy, wheeze, lung function, and exhaled nitric oxide – the GABRIEL Advanced Studies. Accepted for publication in J All Clin Immunol 2012.
2. Stöcklin L, Loss G, von Mutius E, Genuneit J, Horak E, Braun-Fahrländer C, the GABRIELA Study Group. Health-related quality of life does not explain the protective effect of farming on allergies. Pediatr Allergy Immunol 2012: doi:10.1111/j.1399-3038.2012.01305.x
3. Fuchs O, Singer F, Latzin P, Singer F, Petrus N, Proietti E, Kieninger E, Casaulta C, Frey U. Comparison of online single-breath versus online multiple breath exhaled nitric oxide at school age. Ped Res 2012 May;71(5):605-11. doi: 10.1038/pr.2012.13.
4. Illi S, Depner M, Genuneit J, Horak E, Loss G, Strunz-Lehner C, Büchele G, Boznanski A, Danielewicz H, Cullinan P, Heederik D, Braun-Fahrländer C, von Mutius E, GABRIELA Study Group. Protection from childhood asthma and allergy in farm environments – the GABRIEL Advanced Studies. Accepted for publication in J All Clin Immunol 2012.
5. Loss G, Apprich S, Waser M, Kneifel W, Genuneit J, Büchele G, Weber J, Sozanska B, Danielewicz H, Horak E, van Neerven RJ, Heederik D, Lorenzen PC, von Mutius E, Braun-Fahrländer C, GABRIELA Study Group. The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study. J All Clin Immunol 2011 Oct;128(4):766-773.e4.
6. Regamey N, Tsartsali L, Hilliard TN, Fuchs O, Tan HL, Zhu J, Qiu YS, Alton EW, Jeffery PK, Bush A, Davies JC. Distinct patterns of inflammation in the airway lumen and bronchial mucosa of children with cystic fibrosis. Thorax 2012 Feb;67(2):164-70.
7. Genuneit J, Büchele G, Waser M, Kovacs K, Debinska A, Boznanski A, Strunz-Lehner C, Horak E, Cullinan P, Heederik D, Braun-Fahrländer C, von Mutius E, GABRIELA Study Group. The GABRIEL Advanced Surveys: study design, participation and evaluation of bias. Paed Perinat Epidemiol 2011; doi: 10.1111/j.1365-3016.2011.01223.x.
8. Latzin P, Frey U, Armann J, Kieninger E, Fuchs O, Röösli M, Schaub B. Exposure to Moderate Air Pollution during Late Pregnancy and Cord Blood Cytokine Secretion in Healthy Neonates. PLoS One 2011; 6:e23130
9. Kieninger E, Singer F, Fuchs O, Abbas C, Frey U, Regamey N, Casaulta C, Latzin P. Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects. J Cyst Fibr 2011; doi:10.1016/j.jcf.2011.07.006.
10. Singer F, Stern G, Thamrin C, Fuchs O, Riedel T, Gustafsson P, Frey U, Latzin P. Tidal Volume Single Breath Washout of Two Tracer Gases – A Practical and Promising Lung Function Test. PLoS One 2011; 6:e17588
11. Ege M, von Mutius E, Mayer M, Normand A, Genuneit J, Cookson W, Braun-Fahrländer C, Heederik D, Piarroux R, von Mutius E, GABRIELA Study Group. Exposure to Environmental Microorganisms and Its Inverse Relation to Childhood Asthma. New Engl J Med 2010; 364:701-709.
12. Ege M, Strachan DP, Cookson W, Moffatt M, Gut I, Lathrop M, Kabesch M, Genuneit J, Büchele G, Sozanska B, Boznanski A, Cullinan P, Horak E, Bieli C, Braun-Fahrländer C, Heederik D, von Mutius E, GABRIELA Study Group. Gene-environment interaction for childhood asthma and exposure to farming in Central Europe. J All Clin Immunol 2011; 127:138-144.
13. Fuchs O, Latzin P, Kuehni C, Frey U. Cohort Profile: The Bern Infant Lung Development (BILD) Cohort. Int J Epidemiol 2011; 1-11; doi:10.1093/ije/dyq239.
14. Fuchs O, Latzin P, Thamrin C, Stern G, Frischknecht P, Singer F, Kieninger E, Proietti E, Riedel T, Frey U. Normative data for lung function and exhaled nitric oxide in unsedated healthy infants. Eur Resp J 2011; 37: 1208-1216.
15. Fuchs O, Pfarr N, Pohlenz J, Schmidt H. Elevated serum triiodothyronine and psychomotor retardation with paroxysmal dyskinesia caused by a mutation in the monocarboxylate transporter 8 gene. Dev Med Child Neurol 2009; 51(3):240-4.
16. Fuchs O, Pfarr N, Pohlenz J, Tanner F, Schmidt H. Congenital hypothyroidism (CH) caused by a novel homozygous mutation in the thyroid peroxidase (TPO) gene. J Ped Endo Met 2008; 21(11): 1093-99.
17. Bonfig W, Bechtold S, Bachmann S, Putzker S, Fuchs O, Pagel P, Schwarz HP. Reassessment of the optimal growth hormone cut-off Level in insulin tolerance testing for growth hormone secretion in patients with childhood-onset growth hormone deficiency during transition to adulthood. J Ped Endo Met 2008; 21(11): 1049-57.
18. Janssen N, Meliefste K, Fuchs O, Weiland S, Cassee F, Brunekreef B, Sandstrom T. High and low volume sampling of particulate matter at sites with different trafﬁc proﬁles in the Netherlands and Germany: Results from the HEPMEAP study. Atmospheric Environment 2008; 42: 1110–1120.
19. Bechtold S, Putzker S, Bonfig W, Fuchs O, Dirlenbach I, Schwarz HP. Bone Size Normalizes with age in children and adolescents with type 1 diabetes mellitus. Diabetes Care 2007 Aug; 30(8): 2046-50.
1. Fuchs O, Fuchs S. Chapter 2. Funktionelle Entwicklung der Lunge (Atemmechanik, Gasaustausch). In: von Mutius E, Eber E, Frey U, Gappa M (eds), Pädiatrische Pneumologie, 3. Auflage. Springer Verlag Heidelberg, Germany, to be published in 2012.
2. Fuchs S, Fuchs O. Chapter 11.1. Lungenfunktion - Spirometrie, Plethysmographie, MBW, DLCO, Provokation, Forschungsmethoden, Blutgasanalyse. In: von Mutius E, Eber E, Frey U, Gappa M (eds), Pädiatrische Pneumologie, 3. Auflage. Springer Verlag Heidelberg, Germany, to be published in 2012.
3. Fuchs O. Case Reports on Cystic Fibrosis in Germany and in the US. In: Armstrong E, Fischer M, Parsa-Parsi R, Wetzel M (eds), The Health Care Dilemma, A Comparison of Health Care Systems in Three European Countries and the US. 1st edition, Harvard Medical International, World Scientific, 2011.
Personal Assistant to Professor Erika von Mutius
Alexander Hose, MA MPH
- Master in empirical educational science and educational psychology at the Ludwig-Maximilians-Universität, München (LMU)
- Master in public health and epidemiology at the Ludwig-Maximilians-Universität, München (LMU)
- Research assistant of Prof. von Kries, Institute for Social Pediatrics (LMU), with focus on the evaluation of an obesity prevention program
- Research assistant at the Max Rubner Institute, Federal Research Institute for Nutrition and Food, with focus on longitudinal analyses of effects of various nation-wide obesity prevention programs
- Since October 2012
- Research assistant of Prof. von Mutius at the Children’s Hospital of the LMU, with focus on longitudinal analyses of the PASTURE/EFRAIM birth cohort study
Dr.rer.med. Sabina Illi, MPH
- Diploma in statistics at the Ludwigs-Maximilians-Universität, München
- Master in public health and epidemiology at the Ludwigs-Maximilians-Universität, München
- Doctral degree „Doctor rerum medicarum“ at the Charité, Berlin
- 1994 - 1998
- Research assistant of Prof. Erika von Mutius at the Children's Hospital of the University of Munich: statistical and epidemiological analysis of the Munich Asthma and Allergy Study (MAAS) and the International Study of Asthma and Allergies in Childhood (ISAAC)
- 1998 - 2005
- Research assistant of Prof. Ulrich Wahn at the University Children’s Hospital, Charité, Berlin: statistical and epidemiological analysis of the longitudinal Multicenter Allergy Study (MAS)
- since 2005
- Research assistant of Prof. Erika von Mutius at the Children's Hospital of the University of Munich: statistical and epidemiological analysis of various longitudinal and cross-sectional studies on asthma and allergies in childhood (PAULA, PASTURE/FORALLVENT, PAULCHEN, PAULINA, GABRIEL).
Nicola Korherr, Project Assistant
Since spring 2007 Nicola Korherr has been assisting Erika von Mutius in coordinating the EU projects FORALLVENT and EFRAIM and organizing the fieldwork for the German part of the PASTURE/EFRAIM cohort.
Johanna Kurz, BSc
After three years of professional experience as a nurse at an internistic intensive care unit, Johanna Kurz joined the Asthma and Allergy Research Group in July 2014 as a study nurse to deepen her skills in the field of health sciences, which she gained during her bachelor's studies. She expanded her knowledge with a master's degree, the main project of her master's thesis being: Quality control of lung function measurements to distinguish between different phenotypes of the bronchial asthma in childhood and its precursors. Intermediate analysis of a multicentric cohort study (KIRA-Study, KInder Register Asthma, DZL) and concept development for process and result optimization.
- 2008 - 2013
- Nursing Studies (B.Sc.)at the University of Applied Sciences in Munich
- 2014 - 2016
- Health and Nursing Sciences (M.Sc.) at the Martin-Luther-Universität Halle-Wittenberg in Halle
Dr. rer. nat. Antje Legatzki
Antje Legatzki studied biology with the focus on microbiology at the Martin-Luther-University in Halle. In her diploma and Ph.D. thesis she focused on the investigation of mechanisms for heavy metall resistance in bacteria. From 2007 to 2012 she worked as a postdoctoral researcher in the Soil, Water and Environmental Science department at the University of Arizona, USA. Her area of interest was the characterization of bacterial communities with the main focus on bacterial communities on carbonate formations of Kartchner Caverns (KC). She joined the Asthma and Allergy Group of Professor Erika von Mutius in April 2012. Her interests are the host-environment interactions in the protection from asthma and allergies – with special focus on the microbiome of the environment.
Please follow the link to see publications: Legatzki_publications
Susanne Müller-Rompa, MPH
Susanne Rompa joined the asthma and allergy research group at the Children’s Hospital of the University in Munich in November 2013. The main project of her PhD thesis is the analysis of microbial exposures and their impact on the development of asthma in childhood.
- B.Sc. Biology at the University of Bayreuth and LMU Munich
- Master of Public Health at LMU Munich
(Master thesis: Vitamin D and allergic sensitization in the German EuroPrevall birth cohort)
Dr. med. Barbara Rösler (formerly Unkel), MD
Barbara Unkel graduated from Medical School in Giessen in 2012 and joined the Asthma and Allergy Research Group at the Dr. von Hauner Children‘s Hospital in Munich in 2013. She is working as a clinician researcher in the frame of the German Center for Lung Research. Her focus is on the different phenotypes of wheeze and asthma in childhood in regard to a better understanding of the different molecular and cellular mechanisms involved to improve diagnostics, prevention and therapy.
B. Unkel, K. Högner, B. E. Clausen, P. Lewe-Schlosser, J. Bodner, S. Gattenlöhner, H. Janßen, W. Seeger, J. Lohmeyer, S. Herold “Alveolar epithelial cells orchestrate DC function in murine viral pneumonia“. J Clin Invest. 2012; 122(10):3652-3664
Elisabeth Schmaußer-Hechfellner, BSc
Elisabeth Schmaußer-Hechfellner studied at FernUniversität Hagen and achieved the Bachelor degree in Informatics. In her Bachelor thesis she analyzed the correlations between allergic diseases of children and certain environmental factors using Markov Logic Networks. Before studying she worked as a doctor‘s assistant for nine years. She joined the Asthma and Allergy Group of Professor Erika von Mutius in Mai 2012 and is responsible for data management of the GABRIEL study.